A common condition

Sciatica refers to pain that radiates along the path of the sciatic nerve, which branches from the lower back through the hips and buttocks and down each leg. Typically, sciatica affects only one side of your body.1 The condition affects more than 12 million people in the U.S. (2017).2 It may be caused by physical pressure on the nerves exiting the spinal cord—such as a herniated disc or spinal stenosis—together with an inflammatory component. Risk factors include age, obesity, prolonged sitting, diabetes, and occupations that involve lifting or twisting.

An unmet need

While an estimated 1/3 to 2/3 of people with sciatica will recover with conservative treatments,3 there has been no FDA-approved treatment for the remaining group of patients with persistent pain. Epidural steroid injections (ESIs) are commonly used off-label. They have been shown to provide suboptimal pain relief and come with side effects, including sleeplessness, anxiety, and osteoporosis.4 Opioids are often prescribed, yet are not proven effective for treating sciatica and pose a serious risk of drug dependency.

A new approach

Our Clonidine Micropellet investigational therapy is being developed to provide an innovative treatment that may offer a range of potential benefits. Learn more


of people will
experience sciatica5


of sciatica sufferers
are < 65 years old5


people experience
symptoms for
> 8 weeks5


days of lost work
per person annually
due to sciatica5

The Sollis Clonidine Micropellet therapy is an investigational treatment for sciatica and has not been approved for use by the FDA.

  1. Mayo Clinic,
  2. Sciatica: Epidemiology Forecast to 2028 (2019).
  3. Conservative treatments may include over-the-counter pain medications, physical therapy, heat therapy, oral steroids, and/or chiropractic treatments aimed at relieving pressure on the sciatic nerve.
  4. Research of insurance claims data conducted by Guidehouse Consulting, 2020
  5. Sources: National Institute of Neurological Disorders & Stroke; Harvard Health Network; The Lancet, 2018; JAMA, 2018;